Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy. Ka-Man V. Lai, Michael Gonzalez, William T. Poueymirou, William O. Kline.
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Kerr BA(1), West XZ(1), Kim YW(1), Zhao.
We describe here the use of a novel method to produce a transgenic mouse in which a constitutively active form of Akt can be inducibly expressed in adult.
Surprisingly, Akt shutdown in adult endothelium did not cause acute events leading to lethality. However, gross examination of Akt1ΔEC.
(A) ERKi U0126 failed to trigger significant Erk-Akt crosstalk in adult NP cells, hES-derived NP cells, brain tumor U87 cells, and breast cancer MCF-7 cells in.